this post was submitted on 18 Jul 2024
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Science

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[–] [email protected] 8 points 3 months ago* (last edited 3 months ago) (1 children)

this has been known among users of these drugs for quite a while now. They bond to the same receptors, so they interfere with each other. You can mitigate this a bit by going 24 hours without your SSRI/SNRI (ie skipping the dose that would precede the trip), and increasing dose of the psilocybin by ~1.5x. Or so I hear bee mug emoji

[–] [email protected] 6 points 3 months ago (1 children)

Also pretty dangerous to do MDMA without pausing your SSRIs and just about deadly to do them when on MAOIs

[–] [email protected] 2 points 3 months ago (1 children)

true, but MDMA is a different drug

[–] [email protected] 2 points 3 months ago

Yeah, but its a serotonin agonist, so it has a compounding effect

[–] [email protected] 6 points 3 months ago

Oh yes. Antidepressants have definitely reduced the effectiveness of various drugs for me.

[–] [email protected] 1 points 3 months ago

Can confirm.