You clearly feel a lot more strongly about this than I do.
Life is too short to play bad games. Mario wonder wasn't a bad game for me.
If your gripe is more with nintendo's increasingly poor value proposition, predatory consumer practices and litigious bullshit then there's more of a conversation to be had. I'd suggest your best revenge tools at this point are called Yuzu and Ryujinx.
Perhaps I'm missing the point here. What's wrong with Mario wonder?
3D Mario games have all sucked imo. It's a game that works best in 2D.
Not a bad idea with the kayaks. I just bought a couple of old style geoff barker kayaks/ canoes from an old bloke who does that as a hobby. The old style fibreglass kayaks really lend themselves to easy and quality repair jobs. I felt like we both got a win out of the sale.
They're pretty fun on the water compared to my old plastic behemoths. So easy to load and unload and takes almost zero energy input to paddle. Bloody easy to tip them over though!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976712/
It's significant. Biggest effect is on efficacy of drug metabolism. There are many such studies.
One size does not fit all here owing to differences in expression of metabolising enzymes and drug transport mechanisms.
No, the Japanese are not aliens but they may require far less of a given drug than a westerner, or far more. This affects the likelihood to experience side effects for any given compound, and their severity.
It's fairly ironic to make this change for Japan whilst elsewhere in the world with more racially mixed populations there has been a push in the opposite direction: a recognition that you cannot assume the results of a trial carried out on white male subjects will apply to those of African descent for example.
It's not just drug treatments either. There are many aspects of medical care which have suffered from a lack of specificity and systemic bias.
If you're considering a side hustle, the best one is preparing yourself to apply for a job that pays a living wage.
We shouldn't have to work in our downtime to live a good life.
I know enough to believe this isn't a great idea.
Genetic variation in target populations can result in different outcomes for a variety of treatments and is worth testing specifically.
My thoughts exactly. It just seems like SO MUCH WORK. It's difficult enough balancing a career, children and keeping one relationship healthy.
Pretty soon it will ONLY be the pirates that have access to a lot of this content. You should think of it is a global community service.
I strongly advocate for the revival of thou! Thou shalt yield.
That is the bed they made and now the studios must lay in it.
I don't care if they start distributing microSD cards, there MUST be a physical distribution format that is not linked to an online subscription.
Language rarely changes under duress. That's like trying to give yourself a nickname, it just doesn't take.
I feel your frustration. I played New Super Mario Bros. Wii (2009) on an emulator recently and then New Super Mario Bros. 2 (2012). They've literally been selling the same game over and over again for full price for 15 years.
I guess I just take this in another direction. I don't yearn for some new fangled mario with better graphics, I just accept that I'm not going to pay for the same product over and over again.