I made the switch a few weeks ago. While the transition was a little inconvenient, I got everything set up in maybe an hour or two. Performance was wacky for a few hours after that, but it's settled now for my purposes.
You definitely have to finagle the browser with add-ons and other about:config things to make it work for you, but after that yeah I can say I prefer Firefox over Chrome!
Now I just need to deGoogle everything else...
Yeah this is why I still use at least 1 Google Translate extension in addition to the FF one. Need my Chinese man