The most effective medication is the one that actually gets used.
Chetzemoka
joined 1 year ago
You could actually have an allergy. I met one other person who had a mold allergy that was cross reactive with blue cheeses, and had a similar reaction to them
Huh, now that's super interesting.
Ok you and I both have to go to sleep, but now you've got me wondering about the eternal debate amongst our medical residents about benzos vs. barbiturates for acute alcohol withdrawal. I'll have to read up on this some more
Oh you're getting in the weeds now hahaha. Looks like it's primarily GABA_A
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326685/
I just had to look that shit up haha. I've never thought to check into it beyond just "you're not breathing, so I'm about to make you very angry by reversing your high, sorry bro" lol
So, it's interesting, because it's well-known to have effects on the same GABA receptors as benzodiazepines (like Xanax), but none of the addictive, physical dependence problems, and apigenin doesn't respond consistently to the drug we use to reverse benzos (called flumazenil).
So... we're not entirely sure? It could still be the GABA effects that help with sleep. But there's also a host of antiinflammatory neurological effects that probably better explain its efficacy against Alzheimer's, for example.
Now, if you really want to put yourself to sleep, feel free to crawl through this alphabet soup of a research article lol:
Here, I found a good article for you:
https://www.uspharmacist.com/article/assisting-seniors-with-insomnia-a-comprehensive-approach
Literally the only thing that gives me refreshing sleep. (See also: mitochondrial dysfunction that I mentioned in my other comment about CQ10.) Apigenin seems to improve what's called "sleep architecture" in a way that none of the pharmaceuticals I've ever tried do.
Yeah, long QT syndrome is estimated around 1/2000 people. Relatively rare. I fully confess that I'm just traumatized by my personal experiences with patients taking the drug lol
Hahaha, I love working with older folks. They're my favorite patients.
I actually WOULD recommend this for seniors. It does not have any anticholinergic side effects like a lot of pharmaceutical sedatives do, and it doesn't interact with the most common blood pressure or cardiac meds that older folks often take.
I have the same problem with magnesium supplements. Mag glycinate has less of that laxative effect than mag citrate, so she could try that as well.
The only two caveats I would add are: she should definitely tell her doctors she's taking it, as with any OTC supplement. And if she's specifically on a drug called warfarin (Coumadin), she should be very cautious. (Even Tylenol can cause warfarin to build up in the body. Warfarin sucks, so we don't use it as much anymore, but it's not unheard of.)
Hope that helps! (I'm a cardiac nurse. I work with older folks a lot.)
Tenet. I know it became fashionable to hate it, but it's my favorite Christopher Nolan movie because it's just fun to watch, which is not common with Nolan movies.
I think John David Washington and Robert Pattinson have great chemistry. You need to be comfortable with being clueless about what's happening because the story is told from the limited perspective of the main character. If he doesn't know, the audience doesn't know. When he finds out, you find out. So what the movie seems to be "about" shifts a few times based on his perspective and his assumptions.
Yes, it's clearly just an excuse for Christopher Nolan to indulge in impossible looking practical effects scenes and I love it.