this post was submitted on 08 Nov 2023
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Why are they draining it in this way? Poor things.
It’s catch and release so they let them go afterwards where they found them. Horseshoe crab blood is an essential biomedical tool that’s saved countless lives.
What are some example uses for the blood? I’m fascinated.
Thanks for the reply too.
It’s an anticoagulant and can detect the smallest traces of endotoxins in medicine. I’m sure I’m missing some details but there are some great medical journals that detail the process and help explain why it’s $60,000 a gallon.
$15.85 per ml, for a more at scale measurement.
How close is this stuff to HP’s Cyan?
With how much those things cost, I wouldn’t be surprised if some horseshoe crab blood was mixed in to really make the color pop.
I just snorted
Is this why the royals are rich? Because they have blue blood.
I, uh, I may have an economic recovery proposal.
It is not an anticoagulant, quite the opposite actually. The blood (limulus amoebocyte lysate) will coagulate at the slightest hint of gram-negative bacteria and their endotoxins.
It's most likely a defense mechanism against bacterial infections.
It's widely used in medicine to check for bacterial contamination of injectable pharmaceuticals.
Woah. Are horseshoe crabs like other crustaceans in that they eat pretty much anything including/mostly detritus?
If thats the case, than how would it be beneficial to have blood that coagulates so easily?
Wouldn't every meal lead to a crab version of a stroke?
Horseshoe crabs are not crusteceans, they are early chelicerates.
They have an open circulatory system, where the blood (heamolymph) freely spills out of the arteries into surrounding tissues, so a small clot probably wouldn't cause issues. Think of it like a cyst, sometimes if an infection can't be removed by the immune system, your body will just enclose it in a capsule, so it can't spread.
Ahhh that makes sense. That's a pretty cool defense system
They are not crabs nor crustaceans.
Discoveries like this always makes me wonder, who had the idea to try it and why
Where can someone find these horseshoe crabs?
And are they able to be bred in captivity?
Pls respond fast, I’m already driving to home depot to buy the largest above ground pool they have.
On horseshoes, sure why not, and buy two
The blood contains a coagulent which clots in the presence of bacterial toxins. It is extracted and used to ensure that medical equipent and stuff such as vaccines are sterile and safe.
The main use is to detect how much endotoxins (proteins that cause our immune system to react) are present in a sample. This is important because we often use bacteria/fungus/yeast to produce medicine and then remove the microorganism from that medicine. This checks for anything left behind in that process, far more sensitive than any other test or machine can do.
If it wasn't for horseshoe crab blood, creating medicine that is safe for injection would be a lot harder and potentially more dangerous.
Wonder why we can’t just make the coagulant ourselves. Or maybe we can but milking crabs is still cheaper.
My guess without checking would be regulatory. The FDA doesn't want to approve an alternative to an already working method unless it can be shown to truly be an alternative. That testing is lengthy and expensive.
It's not a chemical compound, the active component is an amebocyte. Same reason we can't just make red blood cells and need other humans to donate them.
There have been other attempts at making synthetic coagulants without broad success. The thing that seems to be the most effective at minimizing the horseshoe crab burden is using machines to do the detection and cut down on the amount of LAL needed vs running the test visually.
Here's an interesting article
Here's a description of the bleeding process: https://www.horseshoecrab.org/med/bestpractices.html
It's specifically non-fatal:
It may look uncomfortable to us humans, but keep in mind that horseshoe crabs are not human. What's normal for the spider is chaos for the fly. Granted, it would be kinda weird to be hoisted from your home by a giant ape and forced into a blood drive. It's done as gently as possible though.
Unfortunately the practice often results in death anyway. 30% die in the process.
It also has unforseen consequences in the food chain, so by all means we should look for alternatives.
Thankfully alternatives already exist .
Last I read synthetic LAL was nowhere near scaleable. Bleeding Crabs is very expensive.
Still, I was disappointed to find that a large percentage of released crabs die anyway. Can't find the number, but it's significant. 1/3rd?
Afair estimates put the portion of dead crabs between 10 and 30%. Some might also be unable to reproduce due to the bleeding.
Sadly a lot of the companies harvesting them will just kill and sell them for bait anyways.
Of those that are released, about a third die. Not to say about the decrease in overall fitness, which can lead to them falling prey more easily.
It's obviously a traumatic experience for the animal in the best case scenario and that is going to reflect on their ability to survive in the wild.
Highest chance of survival/low stress
Edit: many do die still. I don’t want to say it’s safe, just safer
That's how blueberry is made Freeze some of this add some structure, let it set, then put it on trees