I've used a US-QWERTY keyboard layout my entire life. I've seen other layouts that do things like reduce the size of the enter/backspace keys, move the pipe operator (|) and can't wrap my head around how I would code on those.
What are your experiences? Are there any layouts that you prefer for coding over US English? Are there any symbols that you have a hard time reaching ($ for example)?
On the ISO keyboards I've seen, the enter key has way more than double the surface area than ANSI, so it's definitely not 'just rotated 90 degrees'. Also these people probably grew up with ISO and struggle with ANSI, just like you probably grew up with ANSI and struggle with ISO.