Bottles has isolation. You can further that with the flatpak version of bottles.
rodbiren
MicroOS has been great for me as well. Run essentially everything as a docker container, manage it using portainer, use caddy as the server/proxy, and everything is easy peasy now. It restarts every night for an update but you can adjust that if needed. Rock solid.
Natural, which is somehow not default. Despite being called natural. Not weighing in ok what is right. Just interesting how the language came to be.
To me it is blocking expression that presents no plausible harm to anyone. Yelling fire in a crowd to start a panic, making a specific threat, and intentionally spreading lies as to defame all strike me as harmful language and should be curtailed somehow. All expression of any kind not plausibly causing harm should be allowed and equal in the market of ideas despite my personal opinion of them which is a bitter pill to swallow when neonazis appear all to common. The is my opinion.
I'm a chronic distro hopper and here is my advice. If you want to try out new OSs make sure to backup your data as the probability of screwing everything up is relatively high. I use syncthing to ensure all documents I have exist outside my laptop so there is no cost to me breaking everything, but you can also just use an external hard drive and not be fancy. Whatever works for you.
Arch really isn't hugely different especially through the Endeavoros route which gives you sane defaults and packages without grinding through documentation. Just be prepared to be the car enthusiast of computing. Car people love understanding internals, messing with stuff, fixing issues that bother them, looking under the hood, asking for help, etc. That is the best analogy for the more, let's just say, enthusiast Linux environments.
Don't let that scare you though. Be prepared to learn a thing or two, backup your data, and make sure you have a backup stick with another OS on it to undo whatever you break and you'll be fine. I think I have literally gone through 100 reinstalls on the low end and everything is fine. Unlike a car your computer is fairly cheap to fix if it is just software.
Nobara is not debian, but it is pretty solid and fast.
I just love 90% of the defaults for Linux mint. People crap on it for not being Wayland or cutting edge in every regard, but it just puts so much old school polish on it.
MicroOS has worked well as a server for me. Run everything as a container. Use caddy and portainer for reverse proxy and container manager respectively. Auto updates, immutable, and has been bulletproof for me for awhile now.