I think the main issue here (I haven't seen it mentioned in the top comments) is that LoL doesn't even have a cheating problem honestly. I've been playing since 2014, off and on, and I think I might have met maybe one scripter (I'm not really sure). Lol has definitely a toxicity problem, but I honestly don't think it has ever had a scripters/cheaters problem, so I really don't understand this. Is it because of bot accounts? Whose games are these bots ruining (never seen them between gold-diamond)? Does it justify a kernel level anti cheat? Honestly, the real problem with this is not the kernel level anti cheat (because I guess that might be useful for games like valorant), it's the fact that this was never really even close to be necessary
Edit: interestingly enough, riot games itself was reporting in 2020 that cheaters and scripters were ruining a very minor fraction of the games. Ref: https://www.leagueoflegends.com/en-us/news/dev/dev-anti-cheat-in-lol-more/
Bringing some data in, riot games itself was reporting that cheating was not that much of a problem really: https://www.leagueoflegends.com/en-us/news/dev/dev-anti-cheat-in-lol-more/
According to the plot we see there, a very very very minor percentage of games was affected by cheaters in 2020, and I honestly doubt the situation has changed. So, until we see new data from riot, I'm calling bullshit on this whole vanguard thing