this post was submitted on 14 Mar 2025
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Science Memes

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[–] [email protected] 7 points 3 days ago* (last edited 3 days ago)

....and all in between, hormonal and/or physically. "Only two genders" is false

[–] [email protected] 13 points 3 days ago* (last edited 2 days ago) (3 children)
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[–] [email protected] 26 points 4 days ago (19 children)

Can someone explain to me how some XX people become cis male?

[–] [email protected] 41 points 4 days ago

De La Chappell syndrome, congenital adrenal hyperplasia, androgen exposure in utero, ovotesticular disorder of of sex development all result in a person with cis male characteristics and in some cases cis male typical genitalia despite having xx chromosomes

[–] [email protected] 40 points 4 days ago

Gene expression is not as straightforward as people think. All sorts of weird shit can happen, and that's not even including gene mutations.

[–] [email protected] 26 points 4 days ago* (last edited 3 days ago) (1 children)

https://static.scientificamerican.com/sciam/assets/File/Pitch_sketch_final.png?w=2000

This is the best resource I've seen to show things relatively simply.

The TL;DR is that a whole "Y" chromosome isn't exactly responsible for "maleness", the SRY gene is. It's normally on the Y chromosome, but mutations can occur placing that gene onto the X chromosome. Inversely, someone could inherit a Y chromosome without that gene, in which case they would develop with female traits.

It's not considered trans because someone with 46XX plus the SRY gene would develop male genitalia, be identified as male at birth, and likely identify themselves as male. For some types of these conditions, there are plenty of people walking around with no clue that their chromosomes don't match their gender.

Disclaimer: I'm not a geneticist, so i could have explained something a little off.

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[–] [email protected] 22 points 4 days ago* (last edited 4 days ago)

I googled it for you.

https://en.wikipedia.org/wiki/XX_male_syndrome

In 90 percent of these individuals, the syndrome is caused by the Y chromosome's SRY gene, which triggers male reproductive development, being atypically included in the crossing over of genetic information that takes place between the pseudoautosomal regions of the X and Y chromosomes during meiosis in the father.[2][7] When the X with the SRY gene combines with a normal X from the mother during fertilization, the result is an XX genetic male. Less common are SRY-negative individuals, those who are genetically females, which can be caused by a mutation in an autosomal or X chromosomal gene.[2] The masculinization of XX males is variable.

[–] [email protected] 18 points 4 days ago

You've heard of xy people and xx people, but wait till you hear about X people!

Or xxx people, or xxy people, or... dies

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[–] [email protected] 19 points 4 days ago* (last edited 4 days ago) (10 children)

How do you know if someone has a PhD.?

They tell you

Never not true

[–] [email protected] 32 points 4 days ago

True, but I do think it was warranted in this case.

[–] [email protected] 26 points 3 days ago (1 children)

Well you don't know people with PhD that don't tell you they have one

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[–] [email protected] 27 points 3 days ago

This is putting confirmation bias to the extreme.

[–] [email protected] 12 points 3 days ago (3 children)

Sometimes they don't tell you and just quietly update all of their usernames...

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[–] [email protected] 15 points 3 days ago (7 children)

I'm a bit uninformed on this; it seems fascinating. Do these things happen due to something unusual during the growth of a fetus? What's the name for this phenomenon?

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[–] [email protected] 19 points 4 days ago (7 children)
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