Enable rpmfusion for media codecs and things like libdvdcss or unrestricted mesa drivers: https://rpmfusion.org/Configuration
https://docs.fedoraproject.org/en-US/quick-docs/installing-plugins-for-playing-movies-and-music/
Fedora comes out of the box with a curated flatpak repo. You might want to replace that with flathub: https://flatpak.org/setup/Fedora
Imho, there's no reason not to enable disk encryption for root. Luks configuration during setup is very straightforward.
If you don't have nvidia graphics, enable uefi and secure boot (no legacy options). Fedora works well with it out of the box.