Jc141 on 1337x and LinuxRulez on torrminatorr have repacks specifically meant to work on linux. You just have to run their bash scripts and it auto decompresses the files and sets everything up for you. Make sure to follow jc141 setup guide on github to make sure you have all the dependencies installed. https://github.com/jc141x/jc141-bash/blob/master/setup/readme.md
For Fitgirl and Dodi repacks, Lutris is probably the easiest. I usually setup my folders similar to jc141. GameName with 2 subfolders called game and prefix. The game folder is my working directory and my prefix folder is my prefix directory. This allows me to have different wine prefixes for each game in case some games have extra dependencies that mess with other games. I point Lutris to the installer exe and run the install then afterwards I switch it to the game exe. I usually use WineGE instead of the default Lutris option for the prefixes.
For KaOsKrew, I use a windows VM with QEMU to unpack and use sftp to transfer the files because I haven't had any luck with getting their installer to work. I do the same with Fitgirl and Dodi repacks that have unarc errors during decompression. Then its just setting up with Lutris as normal.
You can also add non Steam games to Steam and make them use proton, I've only had to do this once with RE0, I couldn't get it to run any other way.
r/linuxcracksupport might be helpful and I think they have a matrix chat too.
