this post was submitted on 04 Sep 2023
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Brain's Weight Switch Found: May Let Us Eat What We Want, Finally (neurosciencenews.com)
submitted 1 year ago by [email protected] to c/[email protected]
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A new discovery reveals that astrocytes, star-shaped cells in the brain, play a key role in regulating fat metabolism and obesity. These cells act on a cluster of neurons, known as the GABRA5 cluster, effectively acting as a “switch” for weight regulation.

The MAO-B enzyme in these astrocytes was identified as a target for obesity treatment, influencing GABA secretion and thus weight regulation.

KDS2010, a selective and reversible MAO-B inhibitor, successfully led to weight loss in obese mice without impacting their food intake, even while consuming a high-fat diet, and is now in Phase 1 clinical trials.

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[–] [email protected] 1 points 1 year ago

You can eat anything you like, as much as you like, followed by a pill. Sound like an environmental and social and poverty-problem disaster. Pretty much a theme of the Hunger Games.