this post was submitted on 14 Nov 2023
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This depends on the antidepressant. Most modern antidepressants have a relatively short half-life in the body. For example the one I'm on now has a half-life of about 10 hours. However one of the first SSRIs and the still most frequently prescribed one, Fluoxetine, has a half life of 4 days for the medication itself and its metabolite has a half-life of up to 10 days. So that one does literally take weeks to fully build up in the blood and that's probably why doctors use that line.
Regardless, even with the shorter half-life drugs it does take a couple of weeks for your brain to adjust to the altered neurotransmitter levels. So even if it's not technically "waiting for it to build up in the blood", the result is the same and it's an easily understandable explanation for doctors to use even if it's not technically correct.