this post was submitted on 09 Mar 2024
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Ew, gross, anticholinergic allergy meds? I'll stick to my third generation Cetirizine Hydrochlorides, thanks.
I didn't know we could be all snobby about allergy meds, but I learn something new everyday.
There’s good reason to be snobby about antihistamines. Second and third generation antihistamines are straight-up better than first generation. No drowsiness and they last longer.
Diphenhydramine, for example, is pretty terrible. The FAA doesn’t let pilots fly for 60 HOURS after taking diphenhydramine because of how impairing it can be without the user realizing. Extended use of anticholinergics has also been linked to dementia, IIRC.
I’m a Fexofenadine Hydrochloride man myself, but I respect any second generation antihistamines and beyond.
(Actually, depending on whom you ask, Cetirizine is sometimes categorized as second generation despite its late arrival. Not sure why.)