this post was submitted on 13 Sep 2023
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A popular nasal decongestant doesn't actually relieve congestion, FDA advisers say (www.npr.org)
submitted 1 year ago by [email protected] to c/[email protected]
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Advisers to the Food and Drug Administration voted unanimously on Tuesday against the effectiveness of the key drug found in popular versions of Sudafed, Dayquil and other medications stocked on store shelves.

The FDA assembled its outside advisers to take another look at phenylephrine, which became the main drug in over-the-counter decongestants when medicines with an older ingredient — pseudoephedrine — were moved behind pharmacy counters. A 2006 law had forced the move because pseudoephedrine can be illegally processed into methamphetamine.

If the FDA follows through on the panel's recommendations, Johnson & Johnson, Bayer and other drugmakers could be required to pull their oral medications containing phenylephrine from store shelves. That would likely force consumers to switch to the behind-the-counter pseudoephedrine products or to phenylephrine-based nasal sprays and drops.

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[–] [email protected] 5 points 1 year ago

The nasal spray form:

But FDA reviewers said their latest assessment reflects new testing insights into how quickly phenylephrine is metabolized when taken by mouth, leaving only trace levels that reach nasal passages to relieve congestion. The drug appears more effective when applied directly to the nose, in sprays or drops, and those products are not under review.

Or just good old Pseudoephedrine, but you have to get it from the pharmacy counter even though it doesn't require a prescription. (Thanks Meth producers) but AFAIU taking any decongestant long term is a bad idea. And Phenylephrine increases blood pressure.