As you can't ditch it for alternatives, I suggest:

• KVM, kernel-based VM for better performance. See this vid about setting it up: https://youtu.be/BgZHbCDFODk Licenses (and cr=cks) should work, judging by the Adobe forums, but you'd have an overhead with Windows running, so you'd greatly win by stripping everything off from it, up to disabling system services or even their Explorer DE (like some gamers did with Win Aero in W7 times, killing it while the game was running).
• Wine (Proton) directly or via Bottles\Lutris\Steam increased it's emulation capabilities and performance in the previous years. It works for highly demanding games, talks OK with my various discrete v-cards, skips the Win10 overhead, shows CC apps not unlike other programs, but it can cause random bugs, apps not communicating right to each other, and activating it may be not as straightforward. Before starting to rely on that, it's better to test your exact worklfow, tools you use, etc.

You'd be probably drown in a question of what Linux distro to choose, considering there's stuff like AV Linux or Pop_OS being recomended for media design. But you'd easily hop from one to another as you go, so it's better to install something as simple as Mint first, and try Adobe workarounds there before moving next.

If you have specific hardware, I'd say that Wacom-like graphic tablets work like they should (tried several pieces, adapted some touchscreen devices, nearly out-of-the-box on modern Linux), but for something else, like controllers that need to talk to your programms in some special way, you'd better google their compatibility or try it yourself. Making a passthru of inputs to VM or taking it's inputs by Wine wouldn't usually be a problem, problems start when this piece needs a specific Win\Mac-only driver, and they can, especially if they are old, have a temper of a feral ghoul. I know that there are a lot of linuxoids creating in different kinds of media, so I'm pretty sure there are some answers on the web, at least for the same manufacturer, series or kind of hardware.

Are you able to run windows in a VM for your software?

Using mint or ?

I used to have the same issue, and booted up a Windows VM for anything I couldn't get working on Linux, like syncing my Polar watch. Now I'm down to only using the VM when doing a firmware update of my Gardena robotic lawn mower, which is like once every second year.

Publisher is being discontinued soon and will be removed from Microsoft 365 installs

For VR, https://lvra.gitlab.io/ is a pretty good resource for the state of VR support on Linux currently. Check their supported hardware table.