Friedrich Nietzsche had a lot to say about this.
Suffering is part of what gives life meaning. If you don't know how hard it can get, you don't know how good it can get as well. And there's good suffering out there. Physical exercise, challenging yourself, testing your potential to see what you can actualize are all sufficient things to do in this life. You don't know what you can do until you try to do it.
Then you have to consider things like morality and knowledge.
We humans (and specifically old, white humans) tend to subject others to a certain kind of suffering through the patriarchy. That's not right. Every human should have a chance to live a good life in contrast to suffering. And the ethical pursuit of morality doesn't have to stop with our specific species of life. Humans also subject hundreds of other biological species to a life of slavery, torture, and death. It is a noble cause to bring freedom to those species, just as it is to bring freedom to Palestinians or Ukrainians or Hong Kongers. Their potential is limited by human made constructs which can just as easily be deconstructed.
Also, the universe is infinite (as far as we can tell). There are many machinations ongoing that cause certain events to happen. Why? Why was my local village destroyed by a rock flying in from space? Why is my town in Texas experiencing freezing temperatures when that's never occurred before? How long do I have to get to higher ground until the tsunami that earthquake caused reaches the coast? It's in our interest to learn about the natural world due to the hazards it brings to our lives, of which reality could end prematurely. Humans are also curious. Why is our universe the way it is? Why can't we live in a 4D reality? Can we even grasp reality? How do I know something caused something else? How confident can we be in those judgements?
The human condition since The Enlightenment has meant we've shifted our epistemological focus away from us towards the greater world around us. If we no longer have an Almighty God which has all the answers and tells us what's good and ill, who does that now? We do!
God is dead. But morality, knowledge, and the good life of flourishing are not.