this post was submitted on 16 Mar 2024
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[โ€“] [email protected] 26 points 8 months ago (7 children)

Does anyone know of a good /r/askscience-like community on Lemmy? I've got lots of questions about horseshoe crabs.

I've never read much about horseshoe crabs before. I knew they were interesting, but they're fascinating! Here's a good summary of some of what we know about them: https://www.earthdate.org/episodes/horseshoe-crabs-living-fossils

Interestingly, because their environment is replete with bacteria and their circulatory system makes them particularly prone to infection, they have developed a zero-tolerance immune system. It kills anything it finds that is abnormal.

I wonder how much impact their immune system has on their stagnant evolution. Does killing all intruders reduce the likelihood of mutations by disallowing viruses and the mutations that they bring? Does their immune system know what their DNA should look like and immediately kill any mutations that it finds?

[โ€“] [email protected] 5 points 8 months ago

I'm guessing it's more of the latter. I really only know about human animals, but we probably make about 50-100 cancerous cells daily (I'm making up the number). Any one of those can become real Cancer^TM if left alone, but our immune system is so efficient at finding and killing these that cancers really only succeed once they have enough good camouflage to masquerade as normal non cancer cells and fool the immune system until it's too late. That's why transplant patients and people with autoimmune diseases are at higher risk of cancer (since they are on immunosuppressants) and boosting the immune system is an effective anti cancer therapy.

That being said honestly I doubt the immune system is hunting down tiny mutations in eggs/sperm or committing entire animal-level suicide after they are successfully fertilized but it's just that it's a harsh environment and they are perfectly evolved to survive there. Any deviation from that perfect form is just so much less fit for survival that their genes never get passed on. And other animals will eventually just become crabs. Like sharks. Every ocean will evolve crabs and sharks.

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