I hesitate to call her a great author in her own right and I detest her attitude towards transwomen. That said, J.K. Rowling's Harry Potter series transformed the young adult fiction genre from a bit of a wasteland of Nancy Drew and Hardy Boy novels into a quality genre with significant cross-generational appeal.
I'll mention Orson Scott Card as well, but his books have worn thin over time as he squeezes every penny out of the Enderverse. Ender's Game got me through a miserable hospital stay as a young child, so it will always have a special place in my heart. Speaker for the Dead I also loved.